Advances in Comparative and Environmental Physiology: Volume by A. D. C. Macknight (auth.), Professor Dr. R. Gilles, Dr. E.

By A. D. C. Macknight (auth.), Professor Dr. R. Gilles, Dr. E. K. Hoffmann, Dr. L. Bolis (eds.)

Advances in Compararative and Environmental Physiology is helping biologists, physiologists, and biochemists retain song of the large literature within the box. delivering finished, built-in reports and sound, severe, and provocative summaries, this sequence is a must for all lively researchers in environmental and comparative body structure. mobile quantity and osmolality in animals is a good studied subject and this particular quantity within the sequence offers the reader with a radical grounding during this sector of body structure. along with elements, the textual content discusses osmolality and quantity regulate when it comes to either inorganic and natural ions which therefore supplies a great evaluate to these operating and attracted to this field.

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Extra info for Advances in Comparative and Environmental Physiology: Volume and Osmolality Control in Animal Cells

Sample text

To achieve this, changes in the availability of transport pathways, particularly basolateral potassium conductance channels, seem to be required. The obvious question - how are such changes initiated and co-ordinated? - has yet to be answered. It is possible that relatively subtle changes in volume are sufficient to produce direct effects on plasma membrane tension, with activation or inactivation of stretch-sensitive potassium channels which have now been identified in several tissues by the patch-clamp technique (Sachs 1987).

The latter would be possible if the activity of the Na-H exchanger exceeded that of the CI-HC0 3 exchanger so that hydrogen ions buffered on anionic groups on non-diffusible cell solutes were lost from the cell, thus making these negative charges available. However, since the sum of the estimated gains of ions accounts only for some 50% of the volume recovery, additional osmotically active cell solutes are also required. As judged by the lack of effects of inhibitors, the observed volume recovery was not dependent on cell calcium nor on intact microfilaments or microtubules (Foskett and Spring 1985).

The latter would be possible if the activity of the Na-H exchanger exceeded that of the CI-HC0 3 exchanger so that hydrogen ions buffered on anionic groups on non-diffusible cell solutes were lost from the cell, thus making these negative charges available. However, since the sum of the estimated gains of ions accounts only for some 50% of the volume recovery, additional osmotically active cell solutes are also required. As judged by the lack of effects of inhibitors, the observed volume recovery was not dependent on cell calcium nor on intact microfilaments or microtubules (Foskett and Spring 1985).

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